Jun started as a post-doc in early 2016. He received his Ph.D. and master’s in Chemical Engineering from Princeton University, and bachelor’s degrees in Mathematics and Bioengineering: Biotechnology from University of California, San Diego. Jun is from South Korea and enjoys traveling there and to nearby countries. In his free time, he plays music (e.g., piano) and sports (e.g., tennis, golf, swimming). He also enjoys learning new things. In the past year he learned sailing and rowing.
A growing concern for 21st-century humanity is the irrevocable rise of carbon dioxide (CO2). Jun’s research has focused on enhancing CO2 fixation by employing thermodynamic and systems-level efficiency of non-photosynthetic carbon-fixing metabolism. He developed a rapid CO2 fixation scheme that enables precise control over the rate of CO2 fixation (i.e., productivity) and the proportion of CO2 incorporated into the product (i.e., yield). His general research interest lies in quantitative and holistic understanding of metabolic networks. Jun aims to apply this knowledge to curing human diseases (e.g., cancer and diabetes) and to optimizing bioprocesses and metabolic engineering to solve energy and environmental issues (e.g., fuel and greenhouse gas).
Email: jopark (at) mit (dot) edu
- Park, J. O., Liu, N., Holinski, K. M., Emerson, D. F., Woolston, B. M., Vidoudez, C., Islam, M. A., Girguis, P. R., Stephanopoulos, G. Enhancing CO2 fixation by balancing reducing power and ATP. in preparation
- Song, Y., Marmion, R. A., Park, J. O., Biswas, D., Rabinowitz, J. D., Shvartsman, S. Y. Dynamic control of dNTP synthesis in early embryos. Developmental Cell 42,1-8 (2017) doi: 10.1016/j.devcel.2017.06.013
- Schober, A. F., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire. O., Reynolds, K. A. An evolutionary module in central metabolism. bioRxiv (2017)
- Hackett, S. R., Zanotelli, V. R. T., Xu, W., Goya, J., Park, J. O., Perlman, D. H., Gibney, P. A., Botstein, D., Storey, J. D., Rabinowitz, J. D. Systems-level analysis of mechanisms regulating yeast metabolic flux. Science 354:aaf2786 (2016) doi: 10.1126/science.aaf2786
- Liu, L., Chen, L., Ducker, G., Park, J. O., Shah, S., Wellen, K. E., Rabinowitz, J. D. Quantification of NADPH balance in cancer. Cancer Research 76(14 Suppl):1013 (2016) doi: 10.1158/1538-7445.AM2016-1013
- Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Shlomi, T., Rabinowitz, J. D. Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nature Chemical Biology 12:482-489 (2016) doi: 10.1038/nchembio.2077
- Bren, A., Park, J. O., Towbin, B. D., Dekel, E., Rabinowitz, J. D., Alon, U. Glucose becomes one of the worst carbon sources for E. coli on poor nitrogen sources due to suboptimal levels of cAMP. Scientific Reports 6:24834 (2016) doi: 10.1038/srep24834
- Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., Rabinowitz, J. D. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nature Chemical Biology 12:345-352 (2016) doi: 10.1038/nchembio.2047
- Mok, W. W. K., Park, J. O., Rabinowitz, J. D., Brynildsen, M. P. RNA futile cycling in model persisters derived from MazF accumulation. mBio 6(6):e01588-15 (2015) doi: 10.1128/mBio.01588-15
- Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. Hierarchy in pentose sugar metabolism in Clostridium Acetobutylicum. Applied and Environmental Microbiology 81:1452-1462 (2015) doi: 10.1128/AEM.03199-14
- Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Rabinowitz, J. D. Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms. Cancer & Metabolism 2(Suppl 1):P54 (2014) doi: 10.1186/2049-3002-2-S1-P54
- Schellenberger, J., Park, J. O., Conrad, T. M., Palsson, B. Ø. BiGG: A Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions. BMC Bioinformatics 11:213 (2010) doi: 10.1186/1471-2105-11-213