Postdoc

Jun started as a post-doc in early 2016. He received his Ph.D. and master’s in Chemical Engineering from Princeton University, and bachelor’s degrees in Mathematics and Bioengineering: Biotechnology from University of California, San Diego. Jun is from South Korea and enjoys traveling there and to nearby countries. In his free time, he plays music (e.g., piano) and sports (e.g., tennis, golf, swimming). He also enjoys learning new things. In the past year he learned sailing and rowing.

A growing concern for 21^st-century humanity is the irrevocable rise of carbon dioxide (CO₂). Jun’s research has focused on enhancing CO₂ fixation by employing thermodynamic and systems-level efficiency of non-photosynthetic carbon-fixing metabolism. He developed a rapid CO₂ fixation scheme that enables precise control over the rate of CO₂ fixation (i.e., productivity) and the proportion of CO₂ incorporated into the product (i.e., yield). His general research interest lies in quantitative and holistic understanding of metabolic networks. Jun aims to apply this knowledge to curing human diseases (e.g., cancer and diabetes) and to optimizing bioprocesses and metabolic engineering to solve energy and environmental issues (e.g., fuel and greenhouse gas).

Email: jopark (at) mit (dot) edu

Publications

Park, J. O., Liu, N., Holinski, K. M., Emerson, D. F., Woolston, B. M., Vidoudez, C., Islam, M. A., Girguis, P. R., Stephanopoulos, G. Enhancing CO2 fixation by balancing reducing power and ATP. in preparation
Song, Y., Marmion, R. A., Park, J. O., Biswas, D., Rabinowitz, J. D., Shvartsman, S. Y. Dynamic control of dNTP synthesis in early embryos. Developmental Cell 42,1-8 (2017) doi: 10.1016/j.devcel.2017.06.013
Schober, A. F., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire. O., Reynolds, K. A. An evolutionary module in central metabolism. bioRxiv (2017)
Hackett, S. R., Zanotelli, V. R. T., Xu, W., Goya, J., Park, J. O., Perlman, D. H., Gibney, P. A., Botstein, D., Storey, J. D., Rabinowitz, J. D. Systems-level analysis of mechanisms regulating yeast metabolic flux. Science 354:aaf2786 (2016) doi: 10.1126/science.aaf2786
Liu, L., Chen, L., Ducker, G., Park, J. O., Shah, S., Wellen, K. E., Rabinowitz, J. D. Quantification of NADPH balance in cancer. Cancer Research 76(14 Suppl):1013 (2016) doi: 10.1158/1538-7445.AM2016-1013
Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Shlomi, T., Rabinowitz, J. D. Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nature Chemical Biology 12:482-489 (2016) doi: 10.1038/nchembio.2077
Bren, A., Park, J. O., Towbin, B. D., Dekel, E., Rabinowitz, J. D., Alon, U. Glucose becomes one of the worst carbon sources for E. coli on poor nitrogen sources due to suboptimal levels of cAMP. Scientific Reports 6:24834 (2016) doi: 10.1038/srep24834
Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., Rabinowitz, J. D. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nature Chemical Biology 12:345-352 (2016) doi: 10.1038/nchembio.2047
Mok, W. W. K., Park, J. O., Rabinowitz, J. D., Brynildsen, M. P. RNA futile cycling in model persisters derived from MazF accumulation. mBio 6(6):e01588-15 (2015) doi: 10.1128/mBio.01588-15
Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. Hierarchy in pentose sugar metabolism in Clostridium Acetobutylicum. Applied and Environmental Microbiology 81:1452-1462 (2015) doi: 10.1128/AEM.03199-14
Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Rabinowitz, J. D. Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms. Cancer & Metabolism 2(Suppl 1):P54 (2014) doi: 10.1186/2049-3002-2-S1-P54
Schellenberger, J., Park, J. O., Conrad, T. M., Palsson, B. Ø. BiGG: A Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions. BMC Bioinformatics 11:213 (2010) doi: 10.1186/1471-2105-11-213