Publications 2017

2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013

2017

X. Chen, C. Zhang, R. Zou, G. Stephanopoulos, and H. Too, “In vitro metabolic engineering of Amorpha-4,11-diene biosynthesis at enhanced rate and specific yield of production.” ACS Syn. Bio., 6 (9), 1691-1700, 2017.
10.1021/acssynbio.6b00377

W. Dong, M.A. Keibler, and G. Stephanopoulos, “Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis.” Metab. Eng., 43, 113-124, 2017.
10.1016/j.ymben.2017.02.002

D.F. Emerson, A. Al Ghatta, B.M. Woolston, A. Fay, A. Kumar, and G. Stephanopoulos, “Theoretical analysis of natural gas recovery from marginal wells with a deep well reactor.” AICHE J., 63 (9), 3642-3650, 2017.
10.1002/aic.15738

J. Xu, N. Liu, K. Qiao, S. Vogg, and G. Stephanopoulos, “Application of metabolic controls for the maximization of lipid production in semicontinuous fermentation,” Proc. Natl. Acad. Sci., 114 (27), E5308-E5316, 2017.
10.1073/pnas.1703321114

J. R. King, B. M. Woolston, and G. Stephanopoulos, “Designing a new entry point into isoprenoid metabolism by exploiting fructose-6-phosphate aldolase side-reactivity in Escherichia coli.” ACS Syn. Bio., 6 (7), 1416-1426, 2017.
10.1021/acssynbio.7b00072

P. Xu, K. Qiao, and G. Stephanopoulos, “Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica,” Biotechnol. Bioeng., 114 (7), 1521–1530, 2017.
10.1002/bit.26285

M. A. Islam, N. Hadadi, M. Ataman, V. Hatzimanikatis, and G. Stephanopoulos, “Exploring biochemical pathways for mono-ethylene glycol (MEG) synthesis from synthesis gas,” Metab. Eng., 41 (December 2016), 173–181, 2017.
10.1016/j.ymben.2017.04.005

Z. J. Li, K. Qiao, N. Liu, and G. Stephanopoulos, “Engineering Yarrowia lipolytica for poly-3-hydroxybutyrate production,” J. Ind. Microbiol. Biotechnol., 44 (4-5), 605–612, 2017.
10.1007/s10295-016-1864-1

A. Okazaki, P. A. Gameiro, D. Christodoulou, L. Laviollette, M. Schneider, F. Chaves, A. Stemmer-Rachamimov, S. A. Yazinski, R. Lee, G. Stephanopoulos, L. Zou, and O. Illiopoulos, “Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers,” J. Clin. Invest., 127 (5), 1631–1645, 2017.
10.1172/JCI87800

J. Yang, F. Cheng, H. Yu, J. Wang, Z. Guo, and G. Stephanopoulos, “Key Role of the Carboxyl Terminus of Hyaluronan Synthase in Processive Synthesis and Size Control of Hyaluronic Acid Polymers,” Biomacromolecules, 18 (4), 1064–1073, 2017.
10.1021/acs.biomac.6b01239

S. Edgar, F. S. Li, K. Qiao, J. K. Weng, and G. Stephanopoulos, “Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate,” ACS Synth. Biol., 6 (2), 201–205, 2017.
10.1021/acssynbio.6b00206

K. Qiao, T. M. Wasylenko, K. Zhou, P. Xu, and G. Stephanopoulos, “Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism,” Nat. Biotechnol.35, 173–177, 2017.
10.1038/nbt.3763

S. M. Davidson, O. Jonas, M. A. Keibler, H. W. Hou, A. Luengo, J. R. Mayers, J. Wyckoff, A. M. Del Rosario, M. Whitman, C. R. Chin, K. J. Condon, A. Lammers, K. A. Kellersberger, B. K. Stall, G. Stephanopoulos, D. Bar-Sagi, J. Han, J. D. Rabinowitz, M. J. Cima, R. Langer, and M. G. Vander Heiden, “Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors,” Nat. Medicine.23, 235–241, 2017.
10.1038/nm.4256

A. E. Vasdekis, A. M. Silverman, and G. Stephanopoulos, “Exploiting bioprocessing fluctuations to elicit the mechanistics of de Novo lipogenesis in Yarrowia lipolytica,” PLoS One, 12 (1), 1–13, 2017.
10.1371/journal.pone.0168889

P. Xu, E. A. Rizzoni, S. Y. Sul, and G. Stephanopoulos, “Improving Metabolic Pathway Efficiency by Statistical Model-Based Multivariate Regulatory Metabolic Engineering,” ACS Synth. Biol., 6 (1), 148–158, 2017.
10.1021/acssynbio.6b00187