Zbigniew Lazar

Visiting Scholar

1

Zbigniew, or Zibi in short, was born in Jastrzębie-Zdrój, Poland. He did his undergraduate and graduate studies in Food Technology and Human Nutrition at Agricultural University of Wrocław, Poland. Later, Zibi received his Ph.D. in biotechnology from Wroclaw University of Environmental and Life Sciences, where he worked on citric acid production and N-glycosylation of proteins in the yeast Yarrowia lipolytica. During his Ph.D. studies he also worked in the laboratory of Markus Aebi at Swiss Federal Institute of Technology for one year, where he focused on N-glycans of Coprinopsis cinerea. His appointment at ETH was funded by the Swiss Federal Scholarship. Prior to attending MIT, Zibi worked as a postdoctoral fellow in the laboratory of Dr. Jean-Marc Nicaud in INRA where he studied biolipid production and sugar utilization by Y. lipolytica. He was a recipient of the AgreenSkills fellowship, co-founded by the European Union.

During his appointment at MIT, funded by “Mobility Plus” fellowship from Polish Ministry of Science and Higher Education, he focuses on synthetic biology and metabolic engineering of biolipid and lipid derived compound production from cheap and renewable raw materials using the yeast Y. lipolytica.

In the free time Zibi likes to read books and travel. Getting to know the world and different cultures is his biggest hobby.

Email: zlazar (at) mit (dot) edu

 

Publications

Hapeta P, Rakicka M, Dulermo R, Gamboa‐Meléndez H, Cruz‐Le Coq AM, Nicaud JM, Lazar Z. 2017. Transforming sugars into fat–lipid biosynthesis using different sugars in Yarrowia lipolytica. Yeast, 34: 293–304

Lazar Z, Neuvéglise C, Rossignol T, Devillers H, Morin N, Robak M, Nicaud JM,
Crutz-Le Coq AM. 2017. Characterization of hexose transporters in Yarrowia lipolytica reveals new groups of Sugar Porters involved in yeast growth. Fungal Genetics and Biology, 100:1-12

Lazar Z, Dulermo T, Neuvéglise C, Crutz-Le Coq AM, Nicaud JM. 2014. Hexokinase—
A limiting factor in lipid production from fructose in Yarrowia lipolytica. Metabolic engineering, 26: 89-99

Rakicka M, Kieroń A, Hapeta P, Neuvéglise C, Lazar Z. 2016. Sweet and sour potential of yeast from the Yarrowia clade. Biomass & Bioenergy, 92: 48-54

Rakicka M, Rukowicz B, Rywińska A, Lazar Z, Rymowicz W. 2016. Technology of efficient continuous erythritol production from glycerol. Journal of Cleaner Production. 139: 905-913,

Ledesma-Amaro R, Lazar Z, Rakicka M, Guo Z, Fouchard F, Crutz-Le Coq AM, Nicaud JM. 2016. Metabolic engineering of Yarrowia lipolytica to produce chemicals and fuels from xylose. Metabolic engineering, 38: 115-124

Rakicka M, Lazar Z, Rywińska A, Rymowicz W. 2016. Efficient utilization of inulin and glycerol as fermentation substrates in erythritol and citric acid production using Yarrowia lipolytica expressing inulinase. Chemical Papers, 70(11): 1452-1459

Rakicka M, Lazar Z, Dulermo T, Fickers P, Nicaud JM. 2015. Lipid production
by the oleaginous yeast Yarrowia lipolytica using industrial by-products under different culture conditions. Biotechnology for Biofuels, 8:104

Lazar Z, Gamboa-Meléndez H, Crutz-Le Coq AM, Neuvéglise C, Nicaud JM. 2015. Awakening the endogenous Leloir pathway for efficient galactose utilisation by Yarrowia lipolytica. Biotechnology for Biofuels, 8: 185

Dulermo T, Lazar Z, Dulermo R, Rakicka M, Haddouche R, Nicaud JM. 2015. Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol cycle in fatty acid synthesis. BBA – Molecular and Cell Biology of Lipids, 1851(9): 1107–1117

Lazar Z, Rossignol T, Verbeke J, Crutz-Le Coq AM, Nicaud JM, Robak M. 2013. Optimized invertase expression and secretion cassette for improving Yarrowia lipolytica growth on sucrose for industrial applications. Journal of Industrial Microbiology
and Biotechnology
, 40(11): 1273-1283

Rywińska A, Juszczyk P, Wojtatowicz M, Robak M, Lazar Z, Tomaszewska L, Rymowicz W. 2013. Glycerol as a promising substrate for Yarrowia lipolytica biotechnological applications. Biomass & Bioenergy, 48: 148-166

Lazar Z, Walczak E, Robak M. 2011. Simultaneous production of citric acid and invertase by Yarrowia lipolytica SUC+ transformants. Bioresource Technology, 102(13): 6982-6989

Robak M, Boruczkowski T, Drożdż W, Lazar Z, Baranowska M, Prządo D. 2011. Application of the yeasts Yarrowia lipolytica for in-situ bioremediation of soil Contaminated with creosote oil – A case study. Ochrona Środowiska, 33(2): 27-33

Buser R, Lazar Z, Käser S, Künzler M, Aebi M. 2010. Identification, characterization, and biosynthesis of a novel N-glycan modification in the fruiting body of the basidiomycete Coprinopsis cinerea. Journal of Biological Chemistry, 285(14): 10715-10723